She devastated Caria and Lycia until she was slain by Bellerophon. In Greek mythology, the chimera was a fire-breathing female monster resembling a lion in the forepart, a goat in the middle,Īnd a dragon behind. He also had immune chimerism, which challenges our current comprehension of antigen presentation and tolerance. Which we suggest be termed cutis bicolor,Īs a result of 2 different genetic backgrounds.
#Chimera definition biology skin#
This boy displayed 2 normal shades of skin color, Interestingly, the ratio of XX to XY cells was expanded in the T-cell subset compared with other peripheral blood mononuclear cell populations.Ĭonclusions This is an exceptional case of human chimerism revealed by abnormal skin pigmentation. The characterization of the HLA haplotypes of the lymphocytes showed that the boy inherited 2 HLA haplotypes from his mother but only 1 from his father. The chimerism was confirmed by the analysis of the red blood cell antigens, which revealed the presence of 2 different populations. We found that his lymphocytes had a normal number of chromosomes, half of them being either 46,XX or 46,XY. Because this pattern of pigmentation might be related to mosaicism, we determined his karyotype. It was not possible to ascertain by means of clinical examination of the patient, his parents, and his brother which of the 2 shades was his normal skin color. He also had 2 lighter Blaschko-linear bands on the lower extremities and an indefinable mixture of lighter and darker skin on the back and the lateral part of the trunk.
#Chimera definition biology Patch#
On examination, we found a disorder of the skin pigmentation that was difficult to categorize there was a lighter-appearing skin patch in the median frontal area and also on one-half of the abdominal area, with a sharp midline demarcation.
Observations The boy had no remarkable previous medical history, and he had normal intelligence and development. We report the case of a 6-year-old boy whose skin pigmentary abnormalities revealed chimerism. Shared Decision Making and Communicationīackground Chimerism, especially in the absence of sexual ambiguity, is extremely rare in humans.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.
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